Last edited by Daikazahn
Thursday, July 30, 2020 | History

6 edition of Sequence-specific DNA binding agents found in the catalog.

Sequence-specific DNA binding agents

Sequence-specific DNA binding agents

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  • 5 Currently reading

Published by RSC Publishing in Cambridge .
Written in English

    Subjects:
  • DNA-drug interactions,
  • DNA-binding proteins,
  • Gene targeting,
  • Drug targeting,
  • Chemotherapy

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Michael Waring.
    SeriesRSC biomolecular sciences
    ContributionsWaring, Michael J., Royal Society of Chemistry (Great Britain)
    Classifications
    LC ClassificationsQP624.75.D77 S46 2006
    The Physical Object
    Paginationxi, 258 p. :
    Number of Pages258
    ID Numbers
    Open LibraryOL17180775M
    ISBN 100854043705
    LC Control Number2007360567

    Sequence-specific DNA Binding Agents. Edited by Michael Waring Article in Angewandte Chemie International Edition 46(15) April with 14 Reads. Identify whether vesicant (DNA or non-DNA binding) or irritant. See the CDHB Cytotoxic and Biotherapy Procedures on administration, safe handling, and disposal of cytotoxic drugs. This must be referred to for full details. Please read before administering chemotherapy.

    Protein binding generally reduces the mobility of a DNA fragment, causing a shift in the location of the fragment band detected by autoradiography. This technique, also referred to as the gel-shift or band-shift assay, is widely used to assay sequence-specific DNA-binding proteins during their purification (Figure ). One advantage of the. DNA binding and cleavage by type I enzymes depend on the presence of “host specificity sites.” Both EcoBI (13) and EcoKI (14), and in fact all type I R–M enzymes, recognize specific bipartite sequences [Scheme , asterisk (*) indicates methylation sites].The general structure consists of a specific heptameric sequence divided into a trimer and a tetramer by nonspecific spacer .

      Different types of designer DNA-binding agents act as powerful sequence-specific gene modulators, by exert-ing their effect from transcription regulation to .   INTRODUCTION. Sequence-specific recognition is an essential criterion to target and control DNA functions for gene-expression, bioimaging, diagnostics, therapeutics and biotechnological applications (1,2).Over the years, many probes have been developed to target DNA, but there is still a pressing need for developing efficient new probes and therapeutic agents .


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Sequence-specific DNA binding agents Download PDF EPUB FB2

The binding of antibiotics and drugs to DNA is a fast developing area of research with important applications in medicine, particularly the treatment of cancer. Sequence-specific DNA Binding Agents uniquely discusses key aspects of this topic, providing a novel perspective on the subject.

Written by experts in the field, this book discusses diverse modes of binding of antibiotics. The binding of antibiotics and drugs to DNA is a fast developing area of research with important applications in medicine, particularly the treatment of ce-specific DNA Binding Agents uniquely discusses key aspects of this topic, providing a novel perspective on the n by experts in the field, this book discusses diverse modes of binding of Pages: Get this from a library.

Sequence-specific DNA binding agents. [Michael J Waring; Royal Society of Chemistry (Great Britain);] -- The binding of antibiotics and drugs to DNA is a fast developing area of research with important applications in medicine, particularly the treatment of cancer.

This book discusses key aspects of. Read the latest chapters of Advances in DNA Sequence-Specific Agents atElsevier’s leading platform of peer-reviewed scholarly literature About the book series. Search in this book series.

Sequence-specific DNA binding by short peptides. Takashi Morii, Keisuke Makino. Download PDF. Sequence-specific DNA Binding Agents Book chapter, Author.

Marcus Wilhelmsson. Chalmers, Chemical and Biological Engineering, Physical Chemistry. Other publications Research. Per Lincoln. Chalmers, Chemical and Biological Engineering, Physical Chemistry Cited by: 1.

The binding of antibiotics and drugs to DNA is a fast developing area of research with important applications in medicine, particularly the treatment of cancer.

Sequence-specific DNA Binding Agents uniquely discusses key aspe. Recent topics that have been addressed include the mechanisms of selective DNA-topoisomerase poisoning by anti tumor agents, sequence-specific recognition of DNA by groove-binding drugs and drug-conjugates, DNA-cleaving anti tumor chromoproteins, application of sequence-specific anti sense and anti-gene therapy in oncology, and mimetics of the.

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents.

DNA-binding metal complexes, peptide and polyamide–DNA interactions, and gene targeting tools are some of the most compelling topics treated in depth. Purchase Advances in DNA Sequence-specific Agents, Volume 4 - 1st Edition. Print Book & E-Book. ISBNTitle:Therapeutic Agents Based on DNA Sequence Specific Binding VOLUME: 15 ISSUE: 14 Author(s):Luke Pett, John A.

Hartley and Konstantinos Kiakos Affiliation:Cancer Research UK Drug- DNA Interactions Research Group, UCL Cancer Institute, Paul O’Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK. Keywords:Alkylating agents, Anticancer chemotherapeutics, Covalent binding, DNA.

Read the latest chapters of Advances in DNA Sequence-Specific Agents atElsevier’s leading platform of peer-reviewed scholarly literature Sign in Register. Journals & Books; Help; Advances in DNA Sequence-Specific Agents.

Latest volume All volumes. Search in this book series. Edited by Graham B. Jones, Brant J. Chapman. Sequence-specific DNA Binding Agents uniquely discusses key aspects of this topic, providing a novel perspective on the subject.

Written by experts in the field, this book discusses diverse modes of binding of antibiotics and drugs to DNA, emphasising matters that are important or promising for cancer treatment.

Get this from a library. Sequence-specific DNA binding agents. [Michael J Waring;] -- This product is not available separately, it is only sold as part of a set.

There are products in the set and these are all sold as one entity. The binding of antibiotics and drugs to DNA is a. Specific activation of transcription initiation by the sequence-specific DNA-binding agents distamycin A and netropsin. Issues that have been addressed include the mechanisms of selective DNA topoisomerase I and II poisoning by antitumor agents (Chapters 1 and 2), sequence-specific recognition of DNA by groove-binding drugs and drug-conjugates (Chapters 3 and 4), recent developments in nitrogen mustard alkylating agents and their potential use for antibody Book Edition: 1.

With the finding that attachment ofEDTA-Fe(II) to a DNA-binding molecule such as methidium creates an efficient DNA-cleaving molecule (at 25°C andpH), attachment ofEDTAto sequence-specific DNA-bindingmolecules was examined (19, 20). TheEDTAattachment converts a sequence-specific DNA-binding.

Advances in DNA Sequence-specific Agents 04 () Sequence-specific DNA binding by short peptides Takashi Morii* and Keisuke Makino Institute of Advanced Energy, Kyoto University, Uji, KyotoJapan 1.

Sequence-specific DNA Binding Agents Search filters. Filters applied. Content Type - all Article Access. Open Access (3) Author Book. Natural Polymers: Volume 1: Composites (1) Themed Collections.

Journal of Materials Chemistry C Recent Review Articles (1). In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.

The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the right cell at the right time and. Sequence-specific DNA-binding small molecules that can permeate cells could potentially regulate transcription of specific genes. Simple pairing rules for the minor groove of the double helix have been developed that allow the design of ligands for predetermined DNA .Gene Ontology Term: sequence-specific DNA binding.

GO ID GO Aspect Molecular Function Description Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.DNA sequence-specificity of DNA- binding proteins!

Sequence-specific interactions! Frequently involve DNA major groove! Base-specific H-bond donor, acceptors, and nonpolar groups are recognized by DNA-binding proteins!

DNA structure can deviate from classic B-form helix, and therefore be specifically recognized by a protein.!